I-Tofacitinib Intermediate (2R, 3R) -2,3-bis [(4-methylbenzoyl) oxy] succinic acid kanye (3R, 4R) – N, 4-dimethyl-1- (phenylmethyl) -3-piperidine amine CAS No. 477600 -71-8

Imithi yethu ye-tofacitinib ibalulekile enqubweni yokukhiqiza i-tofacitinib, umuthi owaziwa kakhulu osetshenziselwa ukwelapha izinhlobo ezithile zesifo samathambo.Lokhu okumaphakathi kudlala indima ebalulekile ekukhiqizweni kwe-tofacitinib, okunomthelela ekusebenzeni kwayo kanye nekhwalithi.Nge-(2R,3R)-2,3-bis[(4-methylbenzoyl)oxy]succinic acid kanye (3R,4R)-N,4-dimethyl-1-(phenylmethyl)- Inhlanganisela enembile ye-3-piperidinamines, yethu umkhiqizo uqinisekisa ukuhlanganiswa kwekhwalithi ephezulu ye-tofacitinib ehlangabezana futhi edlula izindinganiso zomkhakha.

Ifomula yamangqamuzana nesisindo se-tofacitinib yethu emaphakathi ibonisa ubumsulwa namandla ayo, okuyenza ibe yingxenye ethembekile yenqubo yokukhiqiza imithi.Ngezithako zayo ezikalwe ngokucophelela, lokhu okumaphakathi kuqinisekisa ukuvumelana nokusebenza ngempumelelo komkhiqizo wokugcina, i-tofacitinib.Izici zayo zamangqamuzana nazo zifaka isandla ekuzinzeni okuphelele kwe-tofacitinib nempilo yeshelufu, iqinisekisa ukuthi ihlala isebenza futhi ithembekile esikhathini eside.