Khetha Thina
I-JDK ingumnikazi wezindawo zokukhiqiza zekilasi lokuqala kanye nempahla yokuphatha Ikhwalithi, eqinisekisa ukuhlinzekwa okuzinzile kwama-API intermediates.Ithimba lochwepheshe liqinisekisa i-R&D ngomkhiqizo.Ngokuphikisana nakho kokubili, sifuna i-CMO & CDMO emakethe yasekhaya neyamazwe ngamazwe.
Incazelo Yomkhiqizo
I-L-proline tert-butyl ester, eyaziwa nangokuthi i-N-(pyrrolidine-2-carbonyl) -L-proline tert-butyl ester, iyingxenye ebalulekile ezimbonini ezihlukahlukene, kuhlanganise nemithi, ukuhlanganiswa kwamakhemikhali, nezinto ezithuthukisiwe.Ukukhiqiza.Ukuguquguquka kwayo kanye nobubanzi bezinhlelo zokusebenza kuyenza ibe inhlanganisela ebalulekile emizamweni eminingi yesayensi.
Inqubo yokuhlanganiswa komkhiqizo ilandela izindinganiso eziphakeme kakhulu zemboni, iqinisekisa ikhwalithi eyingqayizivele nobumsulwa.Ifomula yamangqamuzana i-C9H17NO2 ihlanganisa izakhi ze-carbon, i-hydrogen, i-nitrogen nomoya-mpilo ukuze kwakhe inhlanganisela enokuqina okukhethekile nokusebenza kabusha.Ngesisindo samangqamuzana angu-171.24, singaphathwa kalula futhi silinganiswe ngokunembile endaweni yaselabhorethri.
Impahla ebalulekile ye-L-tert-butyl proline ukusetshenziswa kwayo kabanzi embonini yezemithi.Abacwaningi basebenzisa le nhlanganisela ukuze bahlanganise izakhi ezihlukahlukene zemithi kanye nezithako ezisebenzayo zemithi (ama-API).Isakhiwo salo esiyingqayizivele kanye neqembu elisebenzayo kwenza kube lula ukuthuthukiswa kwezidakamizwa ezintsha ezibhekiswe ezifweni ezithile nezimo zezokwelapha.Ukuhlanzeka nokunemba kwemikhiqizo yethu kuqinisekisa imiphumela enembile kanye nemiphumela ethembekile phakathi nokuthuthukiswa kwezidakamizwa.
![I-Tofacitinib Intermediate (2R, 3R) -2,3-bis [(4-methylbenzoyl) oxy] succinic acid kanye (3R, 4R) – N, 4-dimethyl-1- (phenylmethyl) -3-piperidine amine CAS No. 477600 -71-8](https://cdnus.globalso.com/jdkchemicals/2R-3R-23-bis-4-methylbenzoyl-oxy-succinic-acid-and-3R-4R-N-4-dimethyl-1-phenylmethyl-3-piperidine-amine.jpg)
