Inkcazo
I-tofacitinib yethu ephakathi nayo yaziwa ngokuba yi-cis-1-benzyl-4-methyl-3-methylaminopiperidine dihydrochloride kwaye inenombolo ye-CAS 1062580-52-2.I-intermediate iyisithako esiphambili kwimveliso ye-tofacitinib, ichiza elisetyenziselwa ukunyanga i-rheumatoid arthritis, i-psoriatic arthritis kunye ne-ulcerative colitis.Njengabaphakathi abaphambili kwi-synthesis ye-tofacitinib, iimveliso zethu zibalulekile kubaphandi bamayeza kunye nabavelisi.
Le khompawundi ephakathi idityaniswe ngononophelo ukuze kuqinisekiswe inqanaba eliphezulu lokucoceka kunye nokuhambelana.Ngeenkqubo zethu zokuvelisa zanamhlanje kunye nemilinganiselo engqongqo yokulawula umgangatho, unokuthemba ukuba i-tofacitinib intermediate yethu ihlangabezana neyona migangatho iphezulu yoshishino lobunyulu nozinzo.
I-Tofacitinib Intermediate (3R, 4R) -1-Benzyl-3- (Mmethylamino) -4-Mmethylpiperidine DiHClide inoluhlu olubanzi lwezicelo, okwenza ibe yimpahla ebalulekileyo kuphando lwamachiza kunye neekhemikhali.Ingaba uqhuba uphando lwezemfundo okanye uphuhlisa amayeza, iikhompawundi zethu eziphakathi zibonelela ngezisombululo ezithembekileyo nezingabizi kakhulu kwiimfuno zakho ezithile.
Khetha Thina
I-JDK iphethe izixhobo zokuvelisa iklasi yokuqala kunye nezixhobo zokulawula uMgangatho, oqinisekisa ukunikezelwa okuzinzile kwe-API intermediates.Iqela lobuchwephesha liqinisekisa iR&D ngemveliso.Ngokuchasene nazo zombini, sikhangela i-CMO kunye ne-CDMO kwimarike yasekhaya neyamanye amazwe.