Inkcazo
I-Palbociclib ephakathi 2-amino-5-bromopyridine inombolo ye-CAS 1072-97-5!Le ngqungquthela yomgangatho ophezulu we-intermediate yinxalenye ebalulekileyo kwi-synthesis ye-palbociclib, i-cyclin enamandla kwaye ikhethiweyo ye-cyclin-dependent kinase 4 kunye ne-6 inhibitor.Ifomula yemolekyuli yale intermediate yi-C5H5BrN2 kunye nobunzima bemolekyuli yi-173.01.Isetyenziselwa ukuveliswa kwePalbociclib, ichiza elibalulekileyo elichasene nomhlaza webele.
IPalbociclib, ekwabizwa ngokuba yi-Ibrance, yaziwa ngokubanzi ngokusebenza kwayo ekunyangeni i-hormone receptor-positive kunye ne-HER2-negative advanced or metastatic breast cancer.Njengenxalenye ephambili kwinkqubo yokuvelisa i-palbociclib, i-2-amino-5-bromopyridine yethu ephakathi isisithako esibalulekileyo kwishishini lamachiza.Ukucoceka kwayo okuphezulu kunye nokwakheka kweekhemikhali ezichanekileyo kuyenza ibe yinto ebalulekileyo ekuvelisweni kweli chiza lisindisa ubomi.
Khetha Thina
I-JDK iphethe izixhobo zokuvelisa iklasi yokuqala kunye nezixhobo zokulawula uMgangatho, oqinisekisa ukunikezelwa okuzinzile kwe-API intermediates.Iqela lobuchwephesha liqinisekisa iR&D ngemveliso.Ngokuchasene nazo zombini, sikhangela i-CMO kunye ne-CDMO kwimarike yasekhaya neyamanye amazwe.
