Khetha Thina
I-JDK iphethe izixhobo zokuvelisa iklasi yokuqala kunye nezixhobo zokulawula uMgangatho, oqinisekisa ukunikezelwa okuzinzile kwe-API intermediates.Iqela lobuchwephesha liqinisekisa iR&D ngemveliso.Ngokuchasene nazo zombini, sikhangela i-CMO kunye ne-CDMO kwimarike yasekhaya neyamanye amazwe.
Ingcaciso yeMveliso
I-N-Acetyl-3- (3,5-difluorophenyl) -DL-alanine, okanye ngokulula i-N-acetyl-3-DFA-DL-alanine, i-synthetic amino acid derivative.Idibanisa i-acetyl, i-alanine kunye nezangqa ze-difluorobenzene.Olu lwakhiwo lukhethekileyo lwemolekyuli lunika iipropati ezikhethekileyo, nto leyo eyenza ibe sisixhobo esixabisekileyo kuphando lwamayeza kunye neekhemikhali.
Enye yeempawu eziphawulekayo ze-N-acetyl-3-DFA-DL-alanine kukukwazi ukuvimbela i-enzyme ethile emzimbeni womntu.Esi sithintelo sinokuba nempembelelo enkulu kunyango, ngakumbi kuphuhliso lonyango olutsha lwezifo ezichatshazelwa zii-enzyme ezichongiweyo.Ngaphaya koko, ukukwazi kwayo ukumodareyitha iinkqubo ezithile zebhayoloji ngokunxibelelana ngokukhethayo kunye nee-receptors ezithile kuyenza ibe yi-asethi exabisekileyo kufundo lweendlela ezahlukeneyo zomzimba.
Enye into enyanzelisayo yale khompawundi yinto enokubakho njengebhloko yokwakha ukuhlanganiswa kwezinye iiamolekyu ezinzima.Ukuguquguquka kwayo kuvumela ukudalwa kwezinto ezintsha zeekhemikhali, okwenza kube luncedo kakhulu kwi-chemistry yamayeza kunye nokufunyanwa kweziyobisi.Abaphandi banokusebenzisa iipropathi ezizodwa ze-N-acetyl-3-DFA-DL-alanine ukwenza abaviwa amayeza anoveli kunye neeprofayili eziphuculweyo ze-pharmacological.
Ukongeza, i-N-acetyl-3-DFA-DL-alanine ine-solubility egqwesileyo kwi-solvents eyahlukeneyo ye-polar kunye ne-non-polar, iququzelela ukusetyenziswa kwayo kwiinkqubo ezahlukeneyo zokulinga.Ukuzinza kwayo phantsi kweemeko ezahlukeneyo kuqinisekisa iziphumo ezithembekileyo, ezivumela abaphandi ukuba benze iimvavanyo ezicokisekileyo kwaye bafumane idatha echanekileyo.
Ukucoceka kunye nomgangatho we-N-Acetyl-3-DFA-DL-Alanine kubaluleke kakhulu, kwaye njengomthengisi ozidlayo, siqinisekisa ukuba iimveliso zethu zihlangabezana nemigangatho ephezulu.I-N-Acetyl-3-DFA-DL-Alanine yethu idityaniswe kusetyenziswa iteknoloji yezobugcisa kunye nemilinganiselo engqongqo yokulawula umgangatho wokuqinisekisa ukuhambelana nokuthembeka kwibhetshi nganye.
