Khetha Rona
JDK e na le lisebelisoa tsa tlhahiso ea maemo a pele le lisebelisoa tsa taolo ea boleng, tse netefatsang phepelo e tsitsitseng ea li-intermediate tsa API.Sehlopha sa litsebi se tiisetsa R&D ka sehlahisoa.Khahlanong le bobeli, re batla CMO & CDMO 'marakeng oa lapeng le oa machabeng.
Tlhaloso ea Sehlahisoa
N-Acetyl-3-(3,5-difluorophenyl) -DL-alanine, kapa feela N-acetyl-3-DFA-DL-alanine, ke motsoako oa maiketsetso oa amino acid.E kopanya mehele ea acetyl, alanine le difluorobenzene.Sebopeho sena se ikhethang sa limolek'hule se e fa thepa e ikhethang, e e etsa sesebelisoa sa bohlokoa lipatlisisong tsa meriana le tsa lik'hemik'hale.
E 'ngoe ea litšobotsi tse khethollang N-acetyl-3-DFA-DL-alanine ke bokhoni ba eona ba ho thibela li-enzyme tse itseng' meleng oa motho.Thibelo ena e ka ba le litlamorao tse kholo ho tsa bongaka, haholo ho nts'etsopele ea liphekolo tse ncha bakeng sa mafu a anngoeng ke li-enzyme tse lebisitsoeng ho tsona.Ho feta moo, bokhoni ba eona ba ho hlophisa lits'ebetso tse ling tsa tlhaho ka ho sebelisana le li-receptor tse ikhethileng bo e etsa letlotlo la bohlokoa boithutong ba litsela tse fapaneng tsa 'mele.
Ntho e 'ngoe e tlamang ea motsoako ona ke bokhoni ba eona e le mohaho oa mohaho bakeng sa motsoako oa limolek'hule tse ling tse rarahaneng.Ho feto-fetoha ha eona ho lumella ho theha mekhatlo e mecha ea lik'hemik'hale, e leng ho etsang hore e be molemo haholo k'hemistri ea meriana le ho sibolloa ha lithethefatsi.Bafuputsi ba ka sebelisa hampe thepa e ikhethang ea N-acetyl-3-DFA-DL-alanine ho theha batho ba seng ba ntse ba sebelisa lithethefatsi ba nang le lintlha tse ntlafalitsoeng tsa pharmacological.
Ntle le moo, N-acetyl-3-DFA-DL-alanine e na le solubility e ntle haholo ho li-solvents tse fapaneng tsa polar le tse seng polar, e thusang ts'ebeliso ea eona lits'ebetsong tse fapaneng tsa liteko.Ho tsitsa ha eona tlas'a maemo a fapaneng ho tiisa liphello tse ka tšeptjoang, ho lumella bafuputsi ho etsa liteko tse feletseng le ho fumana lintlha tse nepahetseng.
Bohloeki le boleng ba N-Acetyl-3-DFA-DL-Alanine ke tsa bohlokoa ka ho fetisisa, 'me joaloka mofani oa thepa ea ikhohomosang, re tiisa hore lihlahisoa tsa rona li finyella litekanyetso tse phahameng ka ho fetisisa.N-Acetyl-3-DFA-DL-Alanine ea rona e entsoe ka ho sebelisa theknoloji ea morao-rao le mehato e tiileng ea taolo ea boleng ho netefatsa botsitso le ts'epahalo sehlopheng se seng le se seng.
