Tlhaloso
Nomoro ea CAS 1378865-93-0, Our 4-methyl-2- (1,1,1-trifluoro-2-dimethyl-2-ethyl) pyridine e entsoe ka hloko le ho lekoa ho finyella litekanyetso tse phahameng ka ho fetisisa tsa bohloeki le boleng.E bapala karolo ea bohlokoa ho hlahisoeng ha Alpelisib, phekolo e lebisitsoeng ho bakuli ba nang le mofetše oa matsoele o tsoetseng pele kapa lihlahala tse tiileng tse nang le liphetoho tsa PIK3CA.
Sebaka sena sa Alpelisib se sebetsa e le setsi sa mohaho bakeng sa motsoako oa Alpelisib, se nolofalletsang tlhahiso ea lithethefatsi tse bontšitseng katleho e kholo litekong tsa meriana.Sebopeho se nepahetseng sa lik'hemik'hale tsa li-intermediate tsa rona se tiisa ho lumellana ha bona le katleho ea bona nakong ea ho kopanya, ho kenya letsoho ho hloekeng e phahameng le matla a sehlahisoa sa ho qetela sa meriana.
4-Methyl-2- (1,1,1-trifluoro-2-dimethyl-2-ethyl) pyridine intermediate ke karolo e ka sehloohong ea motsoako oa lik'hemik'hale oa Alpelisib le karolo e ka sehloohong ea ts'ebetso eohle ea tlhahiso.Ka mokhoa o nepahetseng oa limolek'hule le boima ba 'mele, e etselitsoe ho finyella litlhoko tse thata tsa tlhahiso ea meriana, ho netefatsa ho tsitsa le ho tšepahala ha tlhahiso ea Alpelisib.
Khetha Rona
JDK e na le lisebelisoa tsa tlhahiso ea maemo a pele le lisebelisoa tsa taolo ea boleng, tse netefatsang phepelo e tsitsitseng ea li-intermediate tsa API.Sehlopha sa litsebi se tiisetsa R&D ka sehlahisoa.Khahlanong le bobeli, re batla CMO & CDMO 'marakeng oa lapeng le oa machabeng.
