Tofacitinib Intermediate (2R, 3R) -2,3-bis [(4-methylbenzoyl) oxy] succinic acid uye (3R, 4R) - N, 4-dimethyl-1- (phenylmethyl) -3-piperidine amine CAS No. 477600 -71-8

Yedu tofacitinib yepakati yakakosha mukugadzirwa kwe tofacitinib, mushonga unozivikanwa unoshandiswa kurapa mamwe marudzi earthritis.Iyi yepakati inoita basa rakakosha mukugadzirwa kwe tofacitinib, ichibatsira mukuita kwayo uye kunaka.Via (2R, 3R) -2,3-bis[(4-methylbenzoyl)oxy]succinic acid uye (3R,4R)-N,4-dimethyl-1-(phenylmethyl)- Kunyatsobatanidzwa kwe3-piperidinamines, yedu chigadzirwa chinovimbisa synthesis yemhando yepamusoro tofacitinib inosangana uye inodarika zviyero zveindasitiri.

Iyo molecular formula uye huremu hwetofacitinib yedu yepakati inoratidza kuchena kwayo uye simba, zvichiita kuti ive chikamu chakavimbika chekugadzira mishonga.Nezvimiro zvayo zvakayerwa zvakayerwa, iyi yepakati inovimbisa kuenderana uye kushanda kwechigadzirwa chekupedzisira, tofacitinib.Zvimiro zvayo zvemamorekuru zvinobatsirawo mukugadzikana kwetofacitinib uye hupenyu hwesherufu, kuve nechokwadi kuti inoramba ichishanda uye yakavimbika kwenguva refu.