Hitamo
JDK ifite ibikoresho byo mu rwego rwa mbere n’ibikoresho byo gucunga ubuziranenge, byizeza itangwa rihamye ry’abahuza API.Itsinda ryumwuga ryizeza R&D yibicuruzwa.Kurwanya byombi, turimo gushakisha CMO & CDMO kumasoko yimbere mu gihugu no mumahanga.
Ibisobanuro ku bicuruzwa
N-Acetyl-3- (3,5-difluorophenyl) -DL-alanine, cyangwa gusa N-acetyl-3-DFA-DL-alanine, ni intungamubiri ikomoka kuri aside amine.Ihuza impeta ya acetyl, alanine na difluorobenzene.Iyi miterere idasanzwe itanga imiterere idasanzwe, ikagira igikoresho cyagaciro mubushakashatsi bwa farumasi nubumara.
Kimwe mu bintu bitandukanya N-acetyl-3-DFA-DL-alanine nubushobozi bwayo bwo guhagarika imisemburo yihariye mumubiri wumuntu.Uku kubuza gushobora kugira uruhare runini mubuvuzi, cyane cyane mugutezimbere uburyo bushya bwo kuvura indwara ziterwa na enzymes zigenewe.Ikigeretse kuri ibyo, ubushobozi bwayo bwo guhindura inzira zimwe na zimwe z’ibinyabuzima muguhitamo gukorana na reseptors yihariye bituma iba umutungo wingenzi mukwiga inzira zitandukanye za physiologique.
Ubundi buryo bukomeye bwuru ruganda nubushobozi bwarwo nk'inyubako yo guhuza izindi molekile zigoye.Ubwinshi bwayo butuma hashyirwaho ibinyabuzima bishya, bikagira akamaro kanini muri chimie yubuvuzi no kuvumbura ibiyobyabwenge.Abashakashatsi barashobora gukoresha umutungo wihariye wa N-acetyl-3-DFA-DL-alanine kugirango bakore abakandida ibiyobyabwenge bishya bafite imiterere ya farumasi.
Mubyongeyeho, N-acetyl-3-DFA-DL-alanine ifite imbaraga zo gukemura neza mumashanyarazi atandukanye kandi adafite inkingi, yorohereza kuyikoresha muburyo butandukanye bwubushakashatsi.Guhagarara kwayo mubihe bitandukanye bitanga ibisubizo byizewe, bituma abashakashatsi bakora ubushakashatsi bunoze kandi bakabona amakuru yukuri.
Ubuziranenge nubwiza bwa N-Acetyl-3-DFA-DL-Alanine bifite akamaro kanini cyane, kandi nkumutanga wishimye, turemeza ko ibicuruzwa byacu byujuje ubuziranenge.N-Acetyl-3-DFA-DL-Alanine ikomatanyirizwa hamwe hifashishijwe ikoranabuhanga rigezweho hamwe ningamba zikomeye zo kugenzura ubuziranenge kugirango habeho guhuzagurika no kwizerwa muri buri cyiciro.
