Polyethylene glycol is a linear chain structure composed of repeated ethylene oxide groups, with one hydroxyl group at each end, making it a highly polymerized mixture. As the relative molecular weight increases, polyethylene glycol gradually changes from a colorless and odorless viscous liquid to a waxy solid, and its hygroscopicity quickly decreases; The toxicity decreases as the relative molecular weight increases. Polyethylene glycol with a relative molecular weight of over 4000 is neutral, non-toxic, and has good biocompatibility. It is safe for the human body, but still sensitive to temperature.
Polyethylene glycol 6000 is a white waxy solid sheet or granular powder, non-toxic and flame retardant. It is transported as a general chemical, sealed and stored in a dry place. It has strong plasticity, film-forming properties, and the ability to improve drug release from tablets. It is often used as an evaporative blocker in coating peeling and widely used as an adhesive in tablet manufacturing in the pharmaceutical field. It can make the surface of tablets shiny and smooth, and is not easily damaged or adhered. It can also be adjusted for viscosity by adding liquid polyethylene glycol and used as a suppository matrix. Compared with lipophilic matrices, it has many advantages. For example, suppositories with higher melting points can be prepared, which can withstand the effects of high temperature weather; The release of drugs is not affected by melting point; During the storage period, the physical stability is good.
